Manufacturer: Eli Lilly, USA
Pharmaceutical name: Tadalafil
Pack: 4 tabs (20 mg/tab)
Cialis contains Tadalafil and is made by Eli Lilly, USA.
Cialis is an oral drug that is used for treating impotence (the inability to attain or maintain a penile erection). It is in a class of drugs called phosphodiesterase inhibitors that also includes sildenafil (Viagra) and vardenafil (Levitra).
Erection of the penis is caused by the filling of the penis with blood. Filling occurs because the blood vessels that bring blood to the penis increase in size and deliver more blood to the penis, and, at the same time, the blood vessels that take blood away from the penis decrease in size and remove less blood from the penis.
Sexual stimulation that leads to an erection causes the production and release of nitric oxide in the penis. The nitric oxide causes an enzyme, guanylate cyclase, to produce cyclic guanosine monophosphate (cGMP). It is the cGMP that is primarily responsible for increasing and decreasing the size of the blood vessels carrying blood to and from the penis, respectively, and causing the erection. When the cGMP is destroyed by another enzyme, phosphodiesterase-5, the blood vessels return to their normal size, blood leaves the penis, and the erection ends.Tadalafil prevents phosphodiesterase-5 from destroying cGMP so that cGMP stays around longer. The persistence of cGMP leads to a more prolonged engorgement of the penis with blood.
Long-acting type 5 phosphodiesterase isoenzyme inhibitors are a class of drugs currently prescribed for the treatment of erectile dysfunction in males. Tadalafil Citrate was made available after the initial drug, sildenafil citrate, had been on the market for several years. While sharing many of the pharmacokinetic properties and type 5 phosphodiesterase isoenzyme inhibitory activity profiles, there are several differences in the actions of the drugs although for the most part the results experienced by the user are relatively the same. The major difference between the drugs is the active life of tadalafil citrate. By extending the active life of the drug to approximately thirty-six to forty-eight hours, this allows users to be far less restricted in their dosing protocol and, for lack of a better word, spontaneity.
For the purposes of steroid users the use of Cialis is rather limited beyond that of a “recreational” purpose. One exception to this may be once a steroid user is coming off of anabolic-androgenic steroids and have suffered a significant reduction in their ability to perform sexually and/or their sex drive. The use of drugs such as Cialis can help to alleviate some of the difficulty many have during this period of time.
Type 5 phosphodiesterase isoenzyme inhibitors such as tadalafil citrate work by causing the smooth-muscles to relax in the cavernosal arteries. This in turn allows penile vasodilation and erection to occur in response to sexual stimuli. This response allows one to achieve and maintain an erection and will help with doing so for a number of causes of the erectile dysfunction.
The effects produced by type 5 phosphodiesterase isoenzyme inhibitors can include other benefits such as a reduction in blood pressure and exhibiting other cardioprotective properties. This reduction in blood pressure includes a lowering of arterial pressure, systolic and diastolic. Other heart protecting effects such as an improvement in atherosclerotic disease and endothelial function can also be observed with sustained use of the drug. These benefits, while having been proven under clinical settings, have not been put into practice in any substantive way by medical professionals on any large scale.
Nearly all of the research and scientific study of the drug Cialis has been conducted using male subjects. A small number of studies however have been done with female users. For the most part these studies have indicated that for the purpose of sexual function there appears to be a benefit that females could render from the use of Cialis, at this time however not enough research has been completed to be able to make recommendations about the safe and effective use of Cialis for females.
For most individuals, the recommended starting dose of Cialis is 10 mg per day taken before sexual activity. Depending on the adequacy of the response or side effects, the dose may be increased to 20 mg or decreased to 5 mg a day. The effect of Cialis may last up to 36 hours. Individuals who are taking medications that increase the blood levels of Cialis should not exceed a total dose of 10 mg in 72 hours (See drug interactions). Cialis may be taken with or without food since food does not affect its absorption from the intestine.